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Carbapenem resistance in Acinetobacter baumannii , and their importance in hospital‐acquired infections: a scientific review
Author(s) -
Nguyen M.,
Joshi S.G.
Publication year - 2021
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1111/jam.15130
Subject(s) - acinetobacter baumannii , outbreak , intensive care medicine , carbapenem , pathogen , infection control , multiple drug resistance , microbiology and biotechnology , medicine , drug resistance , biology , antibiotics , pseudomonas aeruginosa , virology , bacteria , genetics
Summary Carbapenem is an important therapy for serious hospital‐acquired infections and for the care of patients affected by multidrug‐resistant organisms, specifically Acinetobacter baumannii ; however, with the global increase of carbapenem‐resistant A. baumannii , this pathogen has significantly threatened public health. Thus, there is a pressing need to better understand this pathogen in order to develop novel treatments and control strategies for dealing with A . baumannii . In this review, we discuss an overview of carbapenem, including its discovery, development, classification and biological characteristics, and its importance in hospital medicine especially in critical care units. We also describe the peculiarity of bacterial pathogen, A . baumannii , including its commonly reported virulence factors, environmental persistence and carbapenem resistance mechanisms. In closing, we discuss various control strategies for overcoming carbapenem resistance in hospitals and for limiting outbreaks. With the appearance of strains that resist carbapenem, the aim of this review is to highlight the importance of understanding this increasingly problematic healthcare‐associated pathogen that creates significant concern in the field of nosocomial infections and overall public health.