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Lactobacillus‐ fermented milk products attenuate bone loss in an experimental rat model of ovariectomy‐induced post‐menopausal primary osteoporosis
Author(s) -
Lee C.S.,
Kim J.Y.,
Kim B.K.,
Lee I.O.,
Park N.H.,
Kim S.H.
Publication year - 2021
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1111/jam.14852
Subject(s) - lactobacillus fermentum , lactobacillus plantarum , lactobacillus , ovariectomized rat , osteoporosis , endocrinology , medicine , biology , fermentation , food science , estrogen , lactic acid , bacteria , genetics
Aim In this study, we investigated the anti‐osteoporotic effect of two fermented milk products (FMPs) fermented by Lactobacillus plantarum A41 and Lactobacillus fermentum SRK414 on a rat model of ovariectomy‐induced post‐menopausal primary osteoporosis. Methods and Results The two Lactobacillus FMPs increased the bone volume and bone mineral density (BMD) in ovariectomized (OVX) rats, and normalized the bone biomarkers in the serum. Additionally, they altered the gene expression levels of bone‐metabolism‐related markers. Furthermore, the two Lactobacillus FMPs downregulated bone‐apoptosis‐related genes stimulated by ovariectomy. Interestingly, the Lactobacillus FMPs decreased the levels of inflammation markers in the serum, bone, ileum and colon of the rats. Gut bacterial populations were also affected upon FMP treatment due to increase in the abundance of the genus Lactobacillus and Faecalibacterium prausnitzii . Conclusions Milk products fermented by L. plantarum A41 and L. fermentum SRK414 can exhibit anti‐osteoporotic effects on post‐menopausal osteoporosis via regulating the expression of bone‐metabolism‐related markers. Significance and Impact of the Study The two Lactobacillus FMPs used in the study can be an ideal method that has its potential of treating post‐menopausal osteoporosis instead of drug treatments.