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Association of Myroides odoratimimus in immunocompromized piglets with post weaning multisystemic wasting syndrome
Author(s) -
Choudhary M.,
Choudhary B.K.,
Bera B.C.,
Chaudhari S.P.,
Giri D.K.,
Ghosh R.C.,
Barbuddhe S.B.
Publication year - 2019
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1111/jam.14448
Subject(s) - wasting , medicine , weaning , wasting syndrome , pediatrics
Aim To study the association of opportunistic infection due to Myroides odoratimimus in piglets immunocompromised by porcine circovirus type 2 (PCV2) infection. Methods and Results The clinical samples ( n = 101) were analysed bacteriologically. The isolates were identified by their phenotypes and MALDI TOF‐MS analysis as Myroides species. The phylogram constructed based on nucleotide sequences of the 16S rRNA gene showed identity (~99%) with the M . odoratimimus isolates. The minimum inhibitory concentration values for antibiotics revealed M . odoratimimus to be resistant against carbapenem, cephalosporins, aminoglycosides and fluoroquinolones. The presence of PCV2 in affected tissue samples was confirmed by amplification of the 565 bp region of ORF2 of the PCV2 genome. The topology of the phylogenetic tree grouped the PCV2 with cluster—2d. Conclusions PCV2 being immunosuppressive in nature might have impaired the immunity thereby increasing the susceptibility of immunocompromised piglets to opportunistic pathogens such as M . odoratimimus leading to disease severity and high mortality. The M . odoratimimus isolates were found to be multidrug resistant and evidenced for uncertain clinical relevance and hence could act as hidden source of public health hazard. Significance and Impact of the Study Myroides odoratimimus is a rarely reported human pathogen. We reported the incidence of infection due to seemingly rare isolates of M . odoratimimus causing an outbreak of pneumonia in piglets. This appears, to the best of authors' knowledge, to be the first outbreak due to Myroides recorded in animal clinical cases described in the literature.