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Trends in the serovar and antimicrobial resistance in clinical isolates of Salmonella enterica from cattle and pigs between 2002 and 2016 in Japan
Author(s) -
Kijima M.,
Shirakawa T.,
Uchiyama M.,
Kawanishi M.,
Ozawa M.,
Koike R.
Publication year - 2019
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1111/jam.14431
Subject(s) - salmonella , salmonella enterica , serotype , biology , microbiology and biotechnology , antimicrobial , antibiotic resistance , cefotaxime , multiple drug resistance , ciprofloxacin , drug resistance , virology , veterinary medicine , antibiotics , bacteria , medicine , genetics
Aims Given the significance of Salmonella enterica in both human and animal health, and a recent global dissemination of Salmonella 4,[5],12:i:‐, changes in the prevalent serovars and antimicrobial resistance in clinical isolates of Salmonella from cattle and pigs were investigated in Japan. Methods and Results The serovars and antimicrobial susceptibilities of 1605 Salmonella enterica isolated from cattle ( n = 894) and swine ( n = 711) between 2002 and 2016 were examined. The most common serovar among all samples was Salmonella Typhimurium. However, its monophasic variant with antigenic structure S. 4,[5],12:i:‐, which was first detected in cattle in 2006 and swine in 2010, has been rapidly increasing in incidence and resistance. Resistance rates to cefotaxime and ciprofloxacin were generally low (<10% in the cattle isolates and <5% in the swine isolates); however, isolates resistant to more than five antimicrobials, which often include these antimicrobials, were recently detected in Salmonella Dublin, S . 4,[5],12:i:‐, S . Typhimurium, Salmonella Newport, Salmonella Choleraesuis and Salmonella 6,7:c:‐. Among them, two S . 4,[5],12:i:‐ isolates possessed extended‐spectrum β‐lactamase‐encoding genes; bla SHV‐12 or bla CTX‐M‐55 , respectively, while all the five S . Typhimurium isolates possessed AmpC‐type β‐lactamase gene of bla CMY‐2 . Conclusions S. 4,[5],12:i:‐ has been rapidly increasing and exhibiting a remarkable change in antimicrobial resistance in Japan. Considering certain serovars are characterized by multidrug resistance including medically important antimicrobials, continuous monitoring and appropriate measures are required to protect public health and veterinary husbandry. Significance and Impact of the Study This study presents a trend in the serovars and antimicrobial resistance in clinical isolates of Salmonella from cattle and pigs in Japan, and showed that there were certain types of Salmonella serovars depending on the animal origin which needs more attention.