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Nonactivated titanium‐dioxide nanoparticles promote the growth of Chlamydia trachomatis and decrease the antimicrobial activity of silver nanoparticles
Author(s) -
Bogdanov A.,
Janovák L.,
Lantos I.,
Endrész V.,
Sebők D.,
Szabó T.,
Dékány I.,
Deák J.,
Rázga Z.,
Burián K.,
Virok D.P.
Publication year - 2017
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1111/jam.13560
Subject(s) - chlamydia trachomatis , antimicrobial , nanoparticle , microbiology and biotechnology , titanium dioxide , silver nanoparticle , chlamydia , chemistry , nanotechnology , materials science , biology , virology , metallurgy , immunology
Aims Chlamydia trachomatis and herpes simplex virus (HSV) are the most prevalent bacterial and viral sexually transmitted infections. Due to the chronic nature of their infections, they are able to interact with titanium‐dioxide (TiO 2 ) nanoparticles (NPs) applied as food additives or drug delivery vehicles. The aim of this study was to describe the interactions of these two prevalent pathogens with the TiO 2 NPs. Methods and Results Chlamydia trachomatis and HSV‐2 were treated with nonactivated TiO 2 NPs, silver NPs and silver decorated TiO 2 NPs before infection of HeLa and Vero cells. Their intracellular growth was monitored by quantitative PCR . Unexpectedly, the TiO 2 NPs (100 μg ml −1 ) increased the growth of C. trachomatis by approximately fourfold, while the HSV‐2 replication was not affected. Addition of TiO 2 to silver NPs decreased their antimicrobial activity against C. trachomatis up to 27·92‐fold. Conclusion In summary, nonactivated TiO 2 NPs could increase the replication of C. trachomatis and decrease the antimicrobial activity of silver NPs. Significance and Impact of the Study The food industry or drug delivery use of TiO 2 NPs could enhance the growth of certain intracellular pathogens and potentially worsen disease symptoms, a feature that should be further investigated.