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Biological evaluation of 3‐hydroxybenzyl alcohol, an extrolite produced by Aspergillus nidulans strain KZR ‐132
Author(s) -
Kumar C. Ganesh,
Mongolla P.,
Pombala S.,
Bandi S.,
Babu K.S.,
Ramakrishna K.V.S.
Publication year - 2017
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1111/jam.13450
Subject(s) - antimicrobial , microbiology and biotechnology , strain (injury) , aspergillus nidulans , bacteria , secondary metabolite , biology , metabolite , aspergillus , chemistry , biochemistry , genetics , gene , mutant , anatomy
Aims The aim of the study was to purify and characterize a bioactive compound from Aspergillus nidulans strain KZR ‐132 and its biological evaluation. Methods and Results A bioactive extolite was purified from A. nidulans strain KZR ‐132, and its chemical structure was elucidated as 3‐hydroxylbenzyl alcohol (3‐ HBA ) based on 1 H and 13 C NMR , FT ‐ IR and mass spectroscopic analysis. The antimicrobial efficacy of 3‐ HBA was established against Gram‐positive, Gram‐negative bacteria and different Candida strains. It also showed promising antibiofilm activity against various tested microbial strains. Reactive oxygen species induced by 3‐ HBA treatment on different Candida strains killed most of the cells and showed necrotic effect. It also exhibited dose‐dependent antioxidant and anti‐inflammatory activities. Conclusions This bioactive extrolite produced by A. nidulans isolated from a niche habitat was demonstrated to possess significant biotechnological and pharmacological potential since it exhibited broad‐spectrum antimicrobial and antibiofilm activities which are reported for the first time. Significance and Impact of the Study The overall study demonstrates that 3‐ HBA produced by A. nidulans KZR ‐132 is a promising bioactive metabolite and possibly can function as a pharmacologically suitable broad‐spectrum antimicrobial drug candidate against various dreaded human‐related bacterial and fungal pathogens.