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Mass spectrometry applied to the identification of Mycobacterium tuberculosis and biomarker discovery
Author(s) -
LópezHernández Y.,
PatiñoRodríguez O.,
GarcíaOrta S.T.,
PinosRodríguez J.M.
Publication year - 2016
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1111/jam.13323
Subject(s) - mycobacterium tuberculosis , tuberculosis , identification (biology) , computational biology , mycobacterium , bacillus (shape) , biology , biomarker discovery , biomarker , microbiology and biotechnology , medicine , proteomics , genetics , pathology , gene , botany
Summary An adequate and effective tuberculosis (TB) diagnosis system has been identified by the World Health Organization as a priority in the fight against this disease. Over the years, several methods have been developed to identify the bacillus, but bacterial culture remains one of the most affordable methods for most countries. For rapid and accurate identification, however, it is more feasible to implement molecular techniques, taking advantage of the availability of public databases containing protein sequences. Mass spectrometry (MS) has become an interesting technique for the identification of TB. Here, we review some of the most widely employed methods for identifying Mycobacterium tuberculosis and present an update on MS applied for the identification of mycobacterial species.