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P enicillium roqueforti : a multifunctional cell factory of high value‐added molecules
Author(s) -
Mioso R.,
Toledo Marante F.J.,
Herrera Bravo de Laguna I.
Publication year - 2015
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1111/jam.12706
Subject(s) - penicillium roqueforti , biology , factory (object oriented programming) , penicillium , chemistry , microbiology and biotechnology , food science , computer science , programming language
Summary This is a comprehensive review, with 114 references, of the chemical diversity found in the fungus P enicillium roqueforti . Secondary metabolites of an alkaloidal nature are described, for example, ergot alkaloids such as festuclavine, isofumigaclavines A and B, and diketopiperazine alkaloids such as roquefortines A–D, which are derived from imidazole. Other metabolites are marcfortines A–C, PR ‐toxin, eremofortines A–E, mycophenolic and penicillic acids, and some γ‐lactones. Also, recent developments related to the structural characteristics of botryodiplodin and andrastin are studied—the latter has anticancer properties. Finally, we discuss the enzymes of P . roqueforti , which can participate in the biotechnological production of high value‐added molecules, as well as the use of secondary metabolite profiles for taxonomic purposes.