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Effect of heat‐killed L actobacillus brevis SBC 8803 on cutaneous arterial sympathetic nerve activity, cutaneous blood flow and transepidermal water loss in rats
Author(s) -
Horii Y.,
Kaneda H.,
Fujisaki Y.,
Fuyuki R.,
Nakakita Y.,
Shigyo T.,
Nagai K.
Publication year - 2014
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1111/jam.12435
Subject(s) - transepidermal water loss , granisetron , hairless , blood flow , serotonin , medicine , endocrinology , receptor , chemistry , anesthesia , pathology , antiemetic , biochemistry , stratum corneum , vomiting
Aim To evaluate the efficacy of the effects of heat‐killed L actobacillus brevis SBC 8803 ( HK‐SBC 8803) on the standard physiological markers of skin health of cutaneous arterial sympathetic nerve activity ( CASNA ), cutaneous blood flow and transepidermal water loss ( TEWL ) and to determine whether SBC 8803 targets serotonin 5‐ HT 3 receptors in rats. Methods and Results A set of three experiments were conducted to examine the effects of SBC 8803 on CASNA , cutaneous blood flow and TEWL using W istar and hairless rats. Two additional experiments further attempted to determine whether HK‐SBC 8803 was targeting the serotonin 5‐ HT 3 receptors by pretreatment with the 5‐ HT 3 antagonist granisetron. Administration of HK‐SBC 8803 in the first three experiments caused marked inhibition of CASNA and significant elevation of cutaneous blood flow under urethane anaesthesia as well as significant decrease in TEWL on the dorsal skin of conscious hairless rats. Pretreatment with granisetron decreased the effects of HK‐SBC 8803 on CASNA and cutaneous blood flow. Conclusions These findings suggest that HK‐SBC 8803 reduces CASNA , increases cutaneous blood flow and decreases TEWL and that 5‐ HT 3 receptors may be involved in CASNA and cutaneous blood flow responses. Significance and Impact of the Study HK‐SBC 8803 could be a useful substance in the treatment/prevention of skin problems, specifically chapped or dry skin.