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Lactobacillus plantarum LG 42 isolated from gajami sik‐hae decreases body and fat pad weights in diet‐induced obese mice
Author(s) -
Park J.E.,
Oh S.H.,
Cha Y.S.
Publication year - 2014
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1111/jam.12354
Subject(s) - university hospital , lactobacillus plantarum , medicine , biology , lactic acid , bacteria , genetics
Abstract Aims This study investigated the antiobesity effect of lactic acid bacteria ( Lactobacillus plantarum LG 42) isolated from gajami sik‐hae. Methods and Results Male C 57 BL /6 J mice were divided into four groups ( n = 10); NDC (normal diet & DW ), HDC (high‐fat diet & DW ), LGLAB (high‐fat diet & Lactobacillus plantarum LG 42, 1 × 10 7 CFU per mouse), HGLAB (high‐fat diet & L. plantarum LG 42, 1 × 10 9 CFU per mouse). After 12 weeks, GLAB supplemented groups showed lower body weight, with a significant reduction in epididymal and back fat. Serum and hepatic triglyceride, serum insulin and leptin levels were significantly lowered in GLAB supplemented groups. The hepatic mRNA expression of PPAR α and CPT ‐I were significantly increased in GLAB groups, whereas the level of ACC , SREBP ‐1 and LXR α were significantly decreased in GLAB groups compared with HDC group. Additionally, GLAB reduces the expression of PPAR γ in the epididymal adipose tissue resulting in inhibition of genes regulated by PPAR γ. Conclusion These results suggest that the L actobacillus plantarum LG 42 has antiobesity effects in high‐fat‐diet‐induced obese mice. Significance and Impact of the Study These results may contribute to nutraceutical and food industries in developing functional food and probiotics based therapies for the treatment and prevention of obesity.