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Wild mushroom extracts potentiate the action of standard antibiotics against multiresistant bacteria
Author(s) -
Alves M.J.,
Ferreira I.C.F.R.,
Lourenço I.,
Castro A.,
Pereira L.,
Martins A.,
Pintado M.
Publication year - 2014
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1111/jam.12348
Subject(s) - microbiology and biotechnology , antibiotics , cefoxitin , ampicillin , ciprofloxacin , clavulanic acid , amoxicillin , biology , bacteria , escherichia coli , chemistry , staphylococcus aureus , biochemistry , genetics , gene
Abstract Aims The main objective of this study was to evaluate the capacity of wild mushroom extracts to potentiate the action of standard antibiotics, through synergisms that allow a decrease in their therapeutic doses and ultimately contribute to the reduction of resistances. Methods and Results Wild mushroom extracts were applied to different multiresistant micro‐organisms ( E scherichia coli , extended‐spectrum beta‐lactamase‐producing ( ESBL ) E . coli and methicillin‐resistant S taphylococcus aureus ( MRSA ), combined with commercial antibiotics (penicillin, ampicillin, amoxicillin/clavulanic acid, cefoxitin, ciprofloxacin, cotrimoxazol, levofloxacin). Microdilution method was used to determine minimum inhibitory concentrations ( MIC s). The results obtained showed higher synergistic effects against MRSA than against E . coli . Mycena rosea and F istulina hepatica were the best extracts for synergistic effects against MRSA . The efficiency of R ussula delica extract against E . coli 1 (resistant to ampicillin, ciprofloxacin and trimethoprim/sulfasoxazole) and E . coli 2 (resistant to amoxicillin/clavulanic acid and ampicillin) was higher than that of L eucopaxillus giganteus extract; nevertheless, the latter extract exhibited better synergistic effects against ESBL E . coli . Conclusions This study shows that, similarly to plants, some mushroom extracts can potentiate the action of antibiotics extensively used in clinical practice for Gram‐positive or Gram‐negative bacteria, with positive action even against multiresistant bacteria. Significance and Impact of the Study Mushroom extracts could decrease therapeutic doses of standard antibiotics and reduce micro‐organism's resistance to those drugs.