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Atopic dermatitis‐mitigating effects of new L actobacillus strain, L actobacillus sakei probio 65 isolated from K imchi
Author(s) -
Kim J.Y.,
Park B.K.,
Park H.J.,
Park Y.H.,
Kim B.O.,
Pyo S.
Publication year - 2013
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1111/jam.12229
Subject(s) - lactobacillus sakei , atopic dermatitis , lactobacillus , strain (injury) , microbiology and biotechnology , food science , biology , immunology , fermentation , anatomy
Aims Atopic dermatitis ( AD ) is an inflammatory skin disease. Probiotics have been reported to modulate immune responses and thus are now being suggested as potential treatments for allergies. In this study, we investigated the inhibitory effects of L actobacillus sakei probio 65 isolated from K imchi on artificially inducing AD in NC / N ga mice. Methods and Results Oral administration of viable or heat‐inactivated L act. sakei probio 65 improved the condition of skin and reduced scratching frequency. Serum levels of I g E and cutaneous T ‐cell‐attracting chemokine ( CTACK ) were significantly decreased by this therapy. Dead L act. sakei probio 65 also decreased IL ‐4 and IL ‐6 serum concentrations. Moreover, both live and dead L act. sakei probio 65 inhibited the expression of Thymus and activation‐regulated chemokine and CTACK in AD ‐like skin lesions. The increased levels of Foxp3 expression in the lesional skin and ears were also suppressed by L act. sakei probio 65. In addition, L act. sakei probio 65 inhibited β‐hexosaminidase release and the secretion of IL ‐4, TNF ‐α and IL ‐6 from RBL ‐2H3 cells. Conclusions Oral treatment with both viable and heat‐inactivated L act. sakei probio 65 inhibits skin inflammation and AD ‐like skin lesions , as well as mast cell activation. Significance and Impact of the Study L actobacillus sakei probio 65 has an inhibitory effect on atopic dermatitis‐like skin lesions and may represent an effective new anti‐inflammatory agent.