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Reduction of aflatoxin level in aflatoxin‐induced rats by the activity of probiotic L actobacillus casei strain S hirota
Author(s) -
Nikbakht Nasrabadi E.,
Jamaluddin R.,
Abdul Mutalib M.S.,
Khaza'ai H.,
Khalesi S.,
Mohd Redzwan S.
Publication year - 2013
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1111/jam.12148
Subject(s) - aflatoxin , lactobacillus casei , probiotic , bioavailability , food science , mycotoxin , lactobacillus , biology , microbiology and biotechnology , bacteria , pharmacology , fermentation , genetics
Aims Aflatoxin B 1 ( AFB 1 ) is considered as the most toxic food contaminant, and microorganisms, especially bacteria, have been studied for their potential to reduce the bioavailability of mycotoxins including aflatoxins. Therefore, this research investigated the efficacy of oral administration of L actobacillus casei S hirota ( L c S ) in aflatoxin‐induced rats. Methods and Results S prague D awley rats were divided into three groups of untreated control, the group induced with AFB 1 only, and the group given probiotic in addition to AFB 1 . In the group induced with AFB 1 only, food intake and body weight were reduced significantly. The liver and kidney enzymes were significantly enhanced in both groups induced with AFB 1 , but they were lower in the group given L c S . AFB 1 was detected from all serum samples except for untreated control group's samples. Blood serum level of AFB 1 in the group induced with AFB 1 only was significantly higher than the group which received probiotic as a treatment ( P < 0·05), and there was no significant difference between the control group and the group treated with probiotic. Conclusions L c S supplementation could improve the adverse effect of AFB 1 induction on rats' body weight, plasma biochemical parameters and also could reduce the level of AFB 1 in blood serum. Significance and Impact of the Study This study's outcomes contribute to better understanding of the potential of probiotic to reduce the bioavailability of AFB 1 . Moreover, it can open an opportunity for future investigations to study the efficacy of oral supplementation of probiotic L c S in reducing aflatoxin level in human.