Premium
Silver‐doped sol‐gel borate glasses: Dose‐dependent effect on Pseudomonas aeruginosa biofilms and keratinocyte function
Author(s) -
Naseri Shiva,
Griffanti Gabriele,
Lepry William C.,
Maisuria Vimal B.,
Tufenkji Nathalie,
Nazhat Showan N.
Publication year - 2022
Publication title -
journal of the american ceramic society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 196
eISSN - 1551-2916
pISSN - 0002-7820
DOI - 10.1111/jace.17802
Subject(s) - biofilm , dissolution , pseudomonas aeruginosa , in vitro , chemistry , wound healing , boron , nuclear chemistry , microbiology and biotechnology , ionic bonding , pseudomonas , bacteria , ion , biochemistry , biology , organic chemistry , genetics , immunology
Borate‐based glasses have generated great interest for wound healing applications due to their ability to incorporate biologically therapeutic ions which can then be released at the site of repair attributable to their high dissolution rates. In this study, the anti‐bacterial activity and cytocompatibility of sol‐gel–derived silver‐doped borate glasses (AgBGs) of the compositional range (60)B 2 O 3 –(36)CaO–(4–x)P 2 O 5 –(x)Ag 2 O, where x = 0.0, 0.3, 0.5, and 1 (mol.%) were investigated, in vitro . The dose‐dependent anti‐bacterial activity of AgBGs was demonstrated against Pseudomonas aeruginosa under both planktonic conditions and pre‐formed biofilms, with up to 99.7% reduction in bacterial cell counts. Lower concentrations of ionic dissolution products from AgBGs were non‐toxic to keratinocytes, stimulating their growth and metabolic activity. Furthermore, compositions containing 0.3 and 0.5 mol.% Ag significantly accelerated the migration of keratinocytes at two different concentrations in an in vitro 2D wound healing model. In summary, these therapeutic AgBGs have demonstrated potential for accelerated wound healing.