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Effects of strontium doping on the degradation and Sr ion release behaviors of α‐tricalcium phosphate bone cement
Author(s) -
Shi Haishan,
Zeng Shenghui,
Liu Xu,
Yu Tao,
Zhou Changren
Publication year - 2018
Publication title -
journal of the american ceramic society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 196
eISSN - 1551-2916
pISSN - 0002-7820
DOI - 10.1111/jace.15220
Subject(s) - strontium , octacalcium phosphate , simulated body fluid , phosphate , biodegradation , degradation (telecommunications) , calcium , materials science , cement , chemical engineering , doping , mineralogy , chemistry , nuclear chemistry , composite material , metallurgy , apatite , organic chemistry , telecommunications , optoelectronics , computer science , engineering
Strontium plays important physicochemical and biological roles in the applications of bone repair materials. The available methods of Sr doping in bone cements were believed to make a key effect on the biodegradation and Sr ion release behaviors of cements. In this work, Sr‐doped octacalcium phosphate (Sr‐OCP), Sr‐doped α‐tricalcium phosphate (Sr‐α‐TCP), SrCO 3 , and SrCl 2 with different actual availability of Sr 2+ were imported into α‐TCP bone cements, and their effects on the biodegradation and ions release of cements were comparatively investigated. Incorporation of different Sr carriers had led to distinct hydration morphologies, crystal evolutions, degradation rates, and microenvironments of bone cements during their in vitro biodegradation. Compared with other Sr carriers, Sr‐OCP facilitated the hydration reaction of α‐TCP, which induced the enhanced degradation and Sr ion release behaviors. In conclusion, Sr‐OCP was supposed to be a more potential Sr carrier applied in the synthesis of biodegradable Sr‐doped calcium phosphate bone cements.