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Cytotoxicity, chemical stability, and surface properties of ferroelectric ceramics for biomaterials
Author(s) -
Acosta Matias,
Detsch Rainer,
Grünewald Alina,
Rojas Virginia,
Schultheiß Jan,
Wajda Aleksandra,
Stark Robert W.,
Narayan Suman,
Sitarz Maciej,
Koruza Jurij,
Boccaccini Aldo R.
Publication year - 2018
Publication title -
journal of the american ceramic society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 196
eISSN - 1551-2916
pISSN - 0002-7820
DOI - 10.1111/jace.15193
Subject(s) - ferroelectricity , wetting , materials science , piezoelectricity , ceramic , cytotoxicity , chemical engineering , chemical stability , contact angle , leaching (pedology) , nanotechnology , mineralogy , composite material , chemistry , in vitro , dielectric , optoelectronics , environmental science , soil science , soil water , biochemistry , engineering
Surface chemistry and topo‐physical properties determine the interactions of biomaterials with their physiological environment. Ferroelectrics hold great promise as the next generation of scaffolds for tissue repair since they feature tunable surface electrical charges, piezoelectricity, and sensing capabilities. We investigate the topography, wettability, chemical stability, and cytotoxicity in salient ferroelectric systems such as (1− x ) (Na 1/2 Bi 1/2 )TiO 3 – x BaTiO 3 , (1− x )Ba(Zr 0.2 Ti 0.8 )O 3 − x (Ba 0.7 Ca 0.3 )TiO 3 , and Pb(Zr,Ti)O 3 to test their suitability as biomaterials. The lead‐free ferroelectrics promote in vitro cell viability and proliferation to a considerably high extent. 0.94 mol % (Na 1/2 Bi 1/2 )TiO 3 –0.06 mol% BaTiO 3 showed the greatest potential leading to a cell viability of (149 ± 30)% and DNA synthesis of (299 ± 85)% in comparison to the reference. Lead leaching from Pb(Zr,Ti)O 3 negatively affected the cultured cells. Wettability and chemical stability are key factors that determine the cytotoxicity of ferroelectrics. These variables have to be considered in the design of novel electroactive scaffolds based on ferroelectric ceramics.