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Hierarchically Designed Bioactive Glassy Nanocoatings for the Growth of Faster and Uniformly Dense Apatite
Author(s) -
Das Indranee,
Medda Samar K.,
De Goutam,
Fagerlund Susanne,
Hupa Leena,
Puska Mervi A.,
Vallittu Pekka K.
Publication year - 2015
Publication title -
journal of the american ceramic society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 196
eISSN - 1551-2916
pISSN - 0002-7820
DOI - 10.1111/jace.13626
Subject(s) - materials science , apatite , simulated body fluid , whitlockite , bioactive glass , chemical engineering , crystallization , calcination , inert , coating , composite number , deposition (geology) , composite material , nanotechnology , scanning electron microscope , chemistry , paleontology , biochemistry , sediment , engineering , biology , catalysis , organic chemistry
Crack‐free bioactive nanocoatings embedded with uniformly distributed silica‐rich bioactive spherical aggregates were successfully prepared in situ by controlling the micellization of a SiO 2 –CaO–P 2 O 5 sol using the tri‐block copolymer P123 followed by dip‐coating onto a bio‐inert glass substrate and calcined. These hierarchically designed nanocoatings embedded with such bioactive glassy nanospheres ( BGNS ) enabled to induce the deposition of a densely populated, uniform, and well‐developed needlelike crystalline carbonated hydroxyapatite coating reminiscence of the mineral phase of natural bone within a short immersion time in simulated body fluid. The BGNS nanocoatings also supported the growth and attachment of human gingival fibroblasts. The results suggest that these newly designed composite nanocoatings are noncytotoxic, capable of supporting rapid and homogeneous calcium phosphate deposition as well as subsequent crystallization, and likely to be promising candidates for inert glass reinforced bone implants.