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Correlation Between Decreased Type‐II Interleukin‐1 Receptor and Increased Monocyte Chemotactic Protein‐1 Expression in the Endometrium of Women with Endometriosis
Author(s) -
KHARFI ABDELAZIZ,
AKOUM ALI
Publication year - 2001
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.8755-8920.2001.450401.x
Subject(s) - endometriosis , endometrium , medicine , immunohistochemistry , proinflammatory cytokine , endocrinology , chemokine , receptor , interleukin , andrology , inflammation , cytokine
PROBLEM: Monocyte chemotactic protein‐1 (MCP‐1), a potent inducer of macrophage recruitment and activation, is overexpressed in the eutopic endometrium of women with endometriosis. Eutopic endometrial cells of women with endometriosis secrete higher levels of MCP‐1 than those of normal women, following stimulation with interleukin‐1 (IL‐1). The aim of this study was to examine whether there is any correlation between the expression of IL‐1 receptor type II (IL‐1RII), a specific downregulator of IL‐1 activity, and that of MCP‐1 in the eutopic endometrium of women with endometriosis.
METHOD OF STUDY: Endometrial biopsies of 46 women with endometriosis and 22 healthy women were evaluated simultaneously for IL‐1RII and MCP‐1 expression by immunohistochemistry.
RESULTS: Our study revealed a highly significant correlation between the decreased expression of IL‐1RII and the increased expression of MCP‐1 in the endometrial tissue of women with endometriosis (Spearman correlation coefficient r=−0.377, P =0.002), particularly in the initial stages of the disease (stages I and II; r=−0.368, P =0.020 and r=−0.480, P =0.002, respectively). Furthermore, this correlation was observed in the proliferative (r=−0.366, P =0.047) and the secretory phases (r=−0.321, P =0.049) of the menstrual cycle.
CONCLUSIONS: These results suggest that the reduced capability of endometrial tissue to downregulate IL‐1 proinflammatory effects may be involved in the increased expression of MCP‐1 in the endometrium of women with endometriosis and the establishment of an inflammatory state. The results also indicate a sustained process of cell activation throughout the menstrual cycle.