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The Immunosuppressive Cytokines Influence the Fetal Survival in Patients with Pregnancy‐Induced Hypertension
Author(s) -
DEL GOBBO VERA,
GIGANTI MARIA GABRIELLA,
ZENOBI ROSSELLA,
PREMROV MARIA GRAZIA,
VILLANI VITTORIO
Publication year - 2000
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.8755-8920.2000.440405.x
Subject(s) - fetus , pregnancy , medicine , cytokine , endocrinology , pathological , interleukin , transforming growth factor , andrology , biology , genetics
PROBLEM: The present study examines the hypothesis that the elevated levels of transforming growth factor (TGF)‐β 1 and interleukin (IL)‐10 would be protective for the fetus survival during pregnancy‐induced hypertension (PIH). Moreover, we evaluate the IL‐12 and IL‐15 serum concentrations and their relationships with PIH.
METHOD OF STUDY: Serum samples were obtained before the onset of labor from control and PIH groups. Cytokine concentrations were determined by Enzyme‐Linked Immunoadsorbent Assay.
RESULTS: Our data show that PIH women have significantly higher TGF‐β 1 and IL‐10 concentrations with respect to control groups ( P =0.0001). Similarly, macrophages from the PIH placentas produce in vitro more elevated TGF‐β 1 and IL‐10 levels compared to normal pregnant ones ( P =0.02), also in the absence of LPS stimulation. IL‐12 and IL‐15 serum concentrations were not detectable in all pregnant groups.
CONCLUSION: We have found that PIH women have elevated concentrations of anti‐inflammatory/immunosuppressive cytokines, suggesting their important role in fetal allograft protection during the normal and pathological pregnancy.