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Intercellular Adhesion Molecule‐1 (ICAM‐1) in Cervicovaginal Fluid of Women Presenting with Preterm Labor: Predictive Value for Preterm Delivery
Author(s) -
MARVIN KEITH W.,
KEELAN JEFFREY A.,
ZHOU REN LI,
MITCHELL MURRAY D.,
COLEMAN* MATTHEW A.G.,
MCCOWAN LESLEY M.E.,
COLEMAN MATTHEW A.G.
Publication year - 2000
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.8755-8920.2000.430504.x
Subject(s) - fetal fibronectin , intercellular adhesion molecule 1 , preterm labor , preterm delivery , medicine , gestation , intercellular adhesion molecule , obstetrics , predictive value , adhesion , receiver operating characteristic , predictive value of tests , positive predicative value , pregnancy , gynecology , cell adhesion molecule , immunology , cell adhesion , biology , chemistry , genetics , organic chemistry
PROBLEM: Clinically useful tests for the prediction and diagnosis of preterm labor and delivery remain to be established. We have hypothesized that soluble intercellular adhesion molecule‐1 (sICAM‐1) in the cervicovaginal fluid of women with preterm labor may be a useful diagnostic tool.
METHOD OF STUDY: The cervicovaginal fluid of 103 women between 24 0 and 33 6 weeks gestation with preterm contractions and intact membranes was assayed for sICAM‐1.
RESULTS: Elevated sICAM‐1 concentrations predicted short intervals to delivery (area under receiver–operator characteristic (ROC) curves, 0.70–0.72 for delivery within 3, 7 and 10 days), with high specificity. Characteristics for delivery within 3 days at a 3 ng/mL threshold for a positive test were sensitivity 33.3%, specificity 98.9%, and positive and negative predictive values of 75.0% and 93.9%, respectively. Predictive ability was independent of and complementary to that of fetal fibronectin (fFN).
CONCLUSIONS: Measurement of sICAM‐1 in cervicovaginal fluid has potential as a predictor of preterm delivery in women with symptoms of preterm labor, particularly in conjunction with fFN testing.