Premium
The Role of Amniotic Fluid Interleukin‐6, and Cell Adhesion Molecules, Intercellular Adhesion Molecule‐1 and Leukocyte Adhesion Molecule‐1, in Intra‐Amniotic Infection
Author(s) -
HSU CHAURDONG,
AVERSA KRISTEN,
MEADDOUGH ERIKA
Publication year - 2000
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.8755-8920.2000.430501.x
Subject(s) - amniotic fluid , intercellular adhesion molecule 1 , adhesion , cell adhesion molecule , intercellular adhesion molecule , chemistry , medicine , andrology , immunology , biology , cell adhesion , pregnancy , fetus , genetics , organic chemistry
PROBLEM: To determine amniotic fluid concentrations and correlations of interleukin‐6 (IL‐6), intercellular adhesion molecule‐1 (ICAM‐1), and leukocyte adhesion molecule‐1 (LAM‐1) in patients with and without intra‐amniotic infection.
METHOD OF STUDY: Fourteen specimens with intra‐amniotic infection and 45 without intra‐amniotic infection were studied. Intra‐amniotic infection was defined as the presence of a positive amniotic fluid culture. Amniotic fluid IL‐6, ICAM‐1, and LAM‐1 levels were determined by an enzyme‐linked immunoassay, and normalized by amniotic fluid creatinine levels.
RESULTS: Amniotic fluid concentrations of IL‐6 and LAM‐1 were significantly higher in patients with than without intra‐amniotic infection. However, amniotic fluid ICAM‐1 concentrations were not significantly different between two groups. Amniotic fluid IL‐6, LAM‐1, and ICAM‐1 were positively correlated.
CONCLUSIONS: Our data indicate that amniotic fluid IL‐6 is significantly associated with an increased adhesion molecule expression in intra‐amniotic infection. However, LAM‐1 plays a more important role than ICAM‐1 in intra‐amniotic infection.