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Vascular Cell Adhesion Molecule‐1 in Normal, Failed, and Ectopic Pregnancy
Author(s) -
DANIEL YAIR,
GAMZU RONI,
LESSING JOSEPH B.,
BARAM AMIRAM,
GEVA ELI,
AMIT AMI,
ESHEDENGLENDER TALMA
Publication year - 2000
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/j.8755-8920.2000.430205.x
Subject(s) - ectopic pregnancy , pregnancy , medicine , endocrinology , andrology , cell adhesion molecule , gestation , adhesion , chemistry , biology , immunology , genetics , organic chemistry
PROBLEM: Vascular cell adhesion molecule‐1 (VCAM‐1) is involved in early pregnancy establishment. This study sought to determine whether soluble VCAM‐1 (sVCAM‐1) serum levels differ among normal, failed, and ectopic pregnancy, its capacity to serve as a marker for pregnancy viability or ectopic pregnancy, and its correlation with serum progesterone and β human chorionic gonadotrophin (βHCG) levels. METHOD OF STUDY: Maternal serum samples were obtained from 20 women with ectopic, 10 with normal, and 10 with failed intra‐uterine pregnancy, all of comparable gestational age. Samples were assayed for sVCAM‐1, progesterone, and βHCG by specific assays. RESULTS: The median serum level of sVCAM‐1 was comparable between the three pregnancy types (normal: 578.3 ng/mL, range 434.4–699.5 ng/mL; failed: 567.8 ng/mL, range 401.9–669.5 ng/mL; and ectopic: 470.7ng/mL range, 328.2–1151.1 ng/mL). Serum levels sVCAM‐1 were not significantly correlated with βHCG or progesterone levels. CONCLUSION: sVCAM‐1 is not appropriate to serve as a marker for pregnancy viability or ectopic pregnancy.