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Prevalence and outcome of non‐alcoholic fatty liver disease in adolescents and young adults undergoing weight loss surgery
Author(s) -
Corey K. E.,
Stanley T. L.,
Misdraji J.,
Scirica C.,
Pratt J.,
Hoppin A.,
Misra M.
Publication year - 2014
Publication title -
pediatric obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.226
H-Index - 69
eISSN - 2047-6310
pISSN - 2047-6302
DOI - 10.1111/j.2047-6310.2014.219.x
Subject(s) - medicine , steatohepatitis , fatty liver , insulin resistance , liver biopsy , weight loss , homeostatic model assessment , gastroenterology , fibrosis , disease , biopsy , surgery , obesity
Summary Background/Objective We evaluated the prevalence of non‐alcoholic fatty liver disease ( NAFLD ) and non‐alcoholic steatohepatitis ( NASH ) in 27 adolescents referred for weight loss surgery ( WLS ). Results On biopsy, 18 patients (66.7%) had NAFLD , and of those, 10 (37.0%) had NASH and 11 (40.7%) had fibrosis. Insulin, HbA1C and homeostatic model assessment of insulin resistance ( HOMA‐IR ) were significantly higher in patients with NASH than those without NASH . Following WLS , 40% of patients with NASH had persistently elevated aminotransferase levels despite weight loss. Conclusion We found that NASH is underdiagnosed in adolescents referred for WLS , and that hyperinsulinaemia, HOMA‐IR and HbA1c can aid in identifying high‐risk patients.