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Obesity, central adiposity and cardiometabolic risk factors in children and adolescents: a family‐based study
Author(s) -
Ali O.,
Cerjak D.,
Kent J. W.,
James R.,
Blangero J.,
Zhang Y.
Publication year - 2014
Publication title -
pediatric obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.226
H-Index - 69
eISSN - 2047-6310
pISSN - 2047-6302
DOI - 10.1111/j.2047-6310.2014.218.x
Subject(s) - medicine , body mass index , waist , obesity , endocrinology , metabolic syndrome , anthropometry , body fat percentage , waist to height ratio , body adiposity index , childhood obesity , cohort , classification of obesity , overweight , fat mass
Summary Objective The objective of this study was to assess genetic and phenotypic correlations of obesity‐related cardiometabolic risk factors in a family‐based cohort. Methods Anthropometric, body composition and biochemical measurements were collected on 999 members of 111 extended M idwestern US families of N orthern E uropean origin. Forward stepwise regression was used to identify which of T anner stage, sex, T anner stage by sex, body fat mass index, body fat percentage (dual‐energy X‐ray absorptiometry), visceral fat ( VF )/subcutaneous fat ( SubQF ) (computed tomography scans for adults or magnetic resonance imaging for children), VF , SubQF , body mass index ( BMI )% and waist to height ratio most influence homeostasis model assessment ( HOMA ), high‐density lipoprotein cholesterol ( HDL ‐c), plasma triglycerides ( TG ) and low‐density lipoprotein cholesterol ( LDL ‐c). Results In children and adolescents, subcutaneous adiposity was the most significant covariate for HOMA ( P < 0.001) and TG ( P = 0.001), and BMI percentile for HDL ‐c ( P = 0.002) and LDL ‐c ( P < 0.001). In adults, waist–height ratio ( P < 0.001), VF / SubQF ratio ( P = 0.001) and BMI ( P = 0.02) were most significant for HOMA ; VF ( P < 0.001) and BMI ( P = 0.02) for TG and VF for LDL ‐c ( P = 0.001). Conclusion Subcutaneous adiposity at the waist is a more significant predictor of metabolic syndrome traits in children and adolescents than it is in adults.