Premium
Compensatory responses to insulin resistance in obese A frican‐ A merican and L atina girls
Author(s) -
Hasson R. E.,
Adam T. C.,
Davis J. N.,
Watanabe R. M.,
Goran M. I.
Publication year - 2013
Publication title -
pediatric obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.226
H-Index - 69
eISSN - 2047-6310
pISSN - 2047-6302
DOI - 10.1111/j.2047-6310.2013.00184.x
Subject(s) - medicine , insulin resistance , insulin , endocrinology , body mass index , pancreatic hormone , glucose tolerance test , area under the curve
Summary Purpose Insulin responses to oral and intravenous glucose markedly differ by ethnicity. This study examined whether ethnic differences in pancreatic insulin secretion, hepatic insulin extraction and clearance explain these disparate findings in 35 obese A frican– A merican and 41 L atina girls (Tanner Stages: IV – V ; ages: 14–18; body mass index percentile: 85.9–99.8%). Methods Pancreatic insulin secretion, hepatic insulin extraction and clearance were estimated by C ‐peptide and insulin modeling during an oral glucose tolerance test. Insulin sensitivity (SI), acute insulin response to glucose ( AIR G ) and disposition index were derived from a frequently sampled intravenous glucose tolerance test. Results Compared to L atinas, obese A frican– A merican adolescents had lower pancreatic insulin secretion (21.3%; P < 0.01), glucose incremental area under the curve ( IAUC ) (41.7%, P = 0.02), C ‐peptide IAUC (25.1%, P < 0.01) and S I (33.7%; P < 0.01). There were no ethnic differences in hepatic insulin extraction and clearance ( P 's > 0.05). Conclusions Compensatory mechanisms to insulin resistance do not appear to explain the ethnic differences in insulin responses to oral and intravenous glucose in obese A frican– A merican and L atina girls.