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Hyperphagia among patients with B ardet‐ B iedl syndrome
Author(s) -
SherafatKazemzadeh R.,
Ivey L.,
Kahn S. R.,
Sapp J. C.,
Hicks M. D.,
Kim R. C.,
Krause A. J.,
Shomaker L. B.,
Biesecker L. G.,
Han J. C.,
Yanovski J. A.
Publication year - 2013
Publication title -
pediatric obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.226
H-Index - 69
eISSN - 2047-6310
pISSN - 2047-6302
DOI - 10.1111/j.2047-6310.2013.00182.x
Subject(s) - medicine
Summary Background The importance of hyperphagia as a cause for energy imbalance in humans with B ardet‐ B iedl syndrome ( BBS ) has not been established. We therefore compared hyperphagic symptoms in patients with BBS vs. controls. Methods: We studied 13 patients with BBS and 23 non‐syndromic controls with similar age, sex and body mass index ( BMI ) z‐score. A 13‐item hyperphagia questionnaire was completed by patients' parents/guardians. Results Total hyperphagia questionnaire score was higher in BBS than controls (27.6 ± 9.0 vs. 19.1 ± 7.9, P = 0.005). Behaviour and drive subscales were higher for BBS than controls (12.5 ± 4.1 vs. 7.8 ± 3.2, P = 0.001, and 11.2 ± 4.1 vs. 8.3 ± 3.8, P = 0.04, respectively); severity was not significantly different between groups (3.8 ± 1.5 vs. 3.0 ± 1.3, P = 0.072). After adjustment for demographic variables and BMI z‐score, total and behaviour subscale scores remained significantly different between groups, suggesting food‐seeking activity, rather than preoccupation with food may be the main hyperphagic feature among patients with BBS .Conclusion Appetite dysregulation may contribute to obesity in BBS .