Premium
Overweight status and intrauterine exposure to gestational diabetes are associated with children's metabolic health
Author(s) -
ChandlerLaney P. C.,
Bush N. C.,
Granger W. M.,
Rouse D. J.,
Mancuso M. S.,
Gower B. A.
Publication year - 2012
Publication title -
pediatric obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.226
H-Index - 69
eISSN - 2047-6310
pISSN - 2047-6302
DOI - 10.1111/j.2047-6310.2011.00009.x
Subject(s) - medicine , overweight , gestational diabetes , endocrinology , body mass index , diabetes mellitus , obesity , insulin , type 2 diabetes , offspring , metabolic syndrome , pregnancy , gestation , biology , genetics
Summary Background Offspring of women with gestational diabetes ( OGD ) have greater risk for obesity and impaired metabolic health. Whether impaired metabolic health occurs in the absence of obesity is not clear. Objective The purpose of this study was to investigate the independent and interactive effects of intrauterine exposure to gestational diabetes and of children's current weight status on their metabolic health. Methods Children aged 5–10 years ( n = 51) with and without intrauterine exposure to gestational diabetes ( OGD vs. offspring of non‐diabetic women [ CTRL ]) were grouped into normal weight (body mass index [ BMI ] < 85th %) and overweight ( BMI > 85th %) according to C enters for D isease C ontrol growth curves. Lipid profile was obtained by fasting blood draw, insulin sensitivity ( S I ) and secretion by liquid meal tolerance test, and body composition by dual‐energy X ‐ray absorptiometry. Results Despite similar average BMI percentiles among normal weight OGD versus CTRL , and overweight OGD vs. CTRL , OGD had greater total %fat and trunk fat adjusted for leg fat compared with CTRL ( P < 0.05). Overweight children had lower S I ( P < 0.05) and greater basal, static, and total insulin secretion independent of S I ( P < 0.05). OGD was independently associated with greater static insulin secretion ( P < 0.05) and the interaction between OGD and overweight was associated with greater basal insulin secretion independent of S I ( P < 0.01). OGD and overweight were each associated with lower high‐density lipoprotein‐cholesterol ( HDL ‐ C ) ( P < 0.05). Conclusion Intrauterine exposure to gestational diabetes was associated with greater central adiposity and insulin secretion, and lower HDL ‐ C , irrespective of current weight status. Future research should examine respective contributions of the intrauterine environment and of underlying genotype on children's metabolic health.