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THE BLOCKING EFFECT OF BENACTYZINE HYDROCHLORIDE ON A BEHAVIOUR DISTURBANCE INDUCED WITH LYSERGIC ACID DIETHYLAMIDE
Author(s) -
GLOW PETER H.
Publication year - 1959
Publication title -
british journal of psychology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.536
H-Index - 92
eISSN - 2044-8295
pISSN - 0007-1269
DOI - 10.1111/j.2044-8295.1959.tb00713.x
Subject(s) - lysergic acid diethylamide , psychology , blocking (statistics) , blocking effect , lysergic acid , hydrochloride , pharmacology , neuroscience , chemistry , developmental psychology , receptor , medicine , stereochemistry , biochemistry , statistics , mathematics , serotonin
The mein interest with lysergic acid diethylamide (LSD‐25) lios with its capacity to mimic most of the clinical features of schizophrenia. It gives rise to short, sharp and transient psychotic disturbances in man and severe behaviour anomalies in animals. These behavioural disorders lend themselves to a systematic analysis. Some consideration has been paid to the development of blocking agents, that is, drugs which can reduce the severity or completely abolish the behavioural effect of LSD‐25. Experiments are described at three levels of inquiry at which it can be shown that benactyzine hydrochloride has a blocking effect on the behavioural disturbance in rats treated with lysergic acid. These experiments were conducted at the physiological, behavioural and pharmacological levels and the observations made are consistent.