Open AccessMetabolism of phenothiazines: identification of N ‐oxygenated products by gas chromatography and mass spectrometry
Author(s) -
ESSIEN E. E.,
COWAN D. A.,
BECKETT A. H.
Publication year - 1975
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1111/j.2042-7158.1975.tb09451.x
Subject(s) - chemistry , mass spectrometry , mass spectrum , promazine , gas chromatography , oxide , chromatography , gas chromatography–mass spectrometry , ion , analytical chemistry (journal) , organic chemistry , chlorpromazine , medicine , endocrinology
The solid inlet mass spectra of the N ‐oxide and N ‐oxide sulphoxide metabolites of promazine, chlorpromazine and methotrimeprazine have been determined at different temperatures and compared with the mass spectra of the main thermolytic product of the N ‐oxides and N ‐oxide sulphoxides obtained during combined gas chromatographymass spectrometry. Diagnostic ions were produced by direct insertion of the compounds at ambient temperature into the mass spectrometer. These ions distinguish the N ‐oxides of arylalkyl tertiary amines from the N ‐oxygenated derivatives of primary and secondary arylalkylamines.