Premium
Suspect novel adverse drug reactions to trimethoprim‐sulphonamide combinations in horses: A case series
Author(s) -
STACK A.,
SCHOTT II H. C.
Publication year - 2011
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/j.2042-3306.2010.00158.x
Subject(s) - foal , medicine , trimethoprim , drug , dose , adverse effect , antimicrobial , adverse drug reaction , drug reaction , antibiotics , intensive care medicine , anesthesia , pharmacology , biology , microbiology and biotechnology , genetics
Summary Adverse drug reactions to trimethoprim‐sulphonamide combinations are common in many species, manifesting as gastrointestinal tract disorders, dermatopathies and blood dyscrasias. In this case series, neurological abnormalities in 4 horses being treated with trimethoprim‐sulphonamide combinations at normal dosages and in one foal that received an overdose are described. The horses developed hypermetric gait, agitation and erratic behaviour. All signs resolved once medication was withdrawn, and no horse had residual deficits. No other cause for observed neurological deficits could be determined. These clinical signs appear to represent a novel adverse drug reaction to some commonly used antimicrobial combinations.