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Effect of acepromazine and butorphanol on halothane minimum alveolar concentration in ponies
Author(s) -
DOHERTY T. J.,
GEISER D. R.,
ROHRBACH B. W.
Publication year - 1997
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/j.2042-3306.1997.tb03142.x
Subject(s) - butorphanol , acepromazine , pony , halothane , anesthesia , saline , medicine , minimum alveolar concentration , blood pressure , heart rate , anesthetic , biology , genetics
Summary The effect of i.v. acepromazine (0.05 mg/kg bwt), butorphanol (0.05 mg/kg bwt) and a combination of acepromazine and butorphanol on halothane minimum alveolar concentration (MAC) was determined in 7 mixed‐breed ponies. Ventilation was controlled, and blood pressure and temperature were maintained within normal limits. Following the determination of baseline MAC, treatments were administered to each pony in a random manner. The control treatment was normal saline. The baseline halothane MAC for the control group was 0.91 ± 0.04%, and no significant change occurred after saline administration. Acepromazine decreased (P = 0.0001) the halothane MAC from mean ± s.e. 0.92 ± 0.02% to 0.58 ± 0.04%, and the combination of acepromazine and butorphanol, decreased (P = 0.003) halothane MAC, from mean ± s.e 0.95 ± 0.04% to 0.59 ± 0.06%. This represents a decrease of 36.9 and 37.8%, respectively. However, the difference between these 2 treatments was not significant. Butorphanol did not significantly change the mean group value for MAC; nevertheless, 3 ponies had an increase, one a decrease, while the MAC did not change in the remaining 3 ponies following butorphanol treatment.