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Pharmacokinetics of ceftriaxone in healthy horses
Author(s) -
RINGGER N. C.,
PEARSON E. G.,
GRONWALL R.,
KOHLEPP S. J.
Publication year - 1996
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/j.2042-3306.1996.tb01620.x
Subject(s) - ceftriaxone , pharmacokinetics , horse , volume of distribution , cerebrospinal fluid , medicine , meningitis , microgram , chemistry , anesthesia , pharmacology , antibiotics , surgery , biology , in vitro , paleontology , biochemistry
Summary Five healthy Equidae (4 horses and one pony) were given a single i.v. dose of ceftriaxone (50 mg/kg bwt) to determine the pharmacokinetics and concentration in cerebrospinal fluid (CSF). Blood was drawn from an i.v. jugular catheter and CSF from a pre‐placed, intrathecal catheter. Serum and CSF concentrations were determined by high performance liquid chromatography. The mean serum concentration of ceftriaxone was 144.7 μg/ml 15 min after injection and declined to 0.3 μg/ml 10 h after injection. The elimination rate constant (Λ 2 ) was 0.63 ± s.e. 0.23/h, the elimination half‐life (t 1/2 ) was 1.62 ± s.e. 0.42 h apparent volume of distribution at steady state (V d(ss) ) was 330.8 ± 11.8 ml/kg bwt. Clearance was 312.7 ± 38 ml/h/kg bwt and mean residence time was 1.13 ± 0.14 h. Mean CSF concentration was 0.60 ± 0.14 μg/ml at 3 h after injection and 0.4 ± 0.31 μg/ml at 8 h. Ceftriaxone may be useful in the treatment of bacterial infections in horses. Its ability to penetrate the CSF should make it effective in the treatment of bacterial meningitis.