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Frusemide attenuates the exercise‐induced rise in pulmonary capillary blood pressure in horses
Author(s) -
MANOHAR M.,
HUTCHENS E.,
CONEY E.
Publication year - 1994
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/j.2042-3306.1994.tb04331.x
Subject(s) - pulmonary wedge pressure , pulmonary artery , medicine , cardiology , furosemide , anesthesia , hemodynamics , blood pressure
Summary Catheter mounted micro‐tip‐manometers (the signals from which were matched with fluid‐filled pressure signals from same cardiovascular sites and zeroed at the point of the shoulder), were used to study pulmonary haemodynamics in 8 healthy sound horses at rest and during exercise performed at 8, 10, 12 and 14 m/s on a treadmill. Measurements were made without frusemide (control) and 4 h after iv administration of 250 mg frusemide. Post‐frusemide data were also obtained on a separate day, and these observations were not significantly different from those made on the same day as controls. Pre‐frusemide values of heart rate, mean right atrial pressure, mean pulmonary artery pressure, mean pulmonary artery wedge pressure and mean pulmonary capillary pressure at 14 m/s were 214 ± 5 beats/min, 54 ± 4, 92 ± 4, 65 ± 6 and 79 ± 5 mmHg, respectively. Exercise at 14 m/s after frusemide resulted in a similar heart rate (216 ± 4 beats/min), but the mean right atrial, pulmonary arterial, pulmonary artery wedge and pulmonary capillary pressures were all significantly lower, i.e. 34 ± 5, 79 ± 4, 45 ± 4, and 62 ± 3 mmHg, respectively. Attenuation, by frusemide, of the exercise‐induced rise in pulmonary capillary pressure would lower the magnitude of the transmural force exerted on the pulmonary capillaries. If, therefore, exercise‐induced pulmonary haemorrhage (EIPH) is caused by stress failure of pulmonary capillaries, frusemide pretreatment has the potential for reducing/limiting the extent of EIPH.