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The airway response of horses with recurrent airway obstruction (heaves) to aerosol administration of ipratropium bromide
Author(s) -
ROBINSON N. E.,
DERKSEN F. J.,
BERNEY C.,
GOOSSENS L.
Publication year - 1993
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/j.2042-3306.1993.tb02967.x
Subject(s) - ipratropium bromide , ipratropium , medicine , anesthesia , airway obstruction , airway resistance , airway , anticholinergic agents , lung volumes , metered dose inhaler , anticholinergic , asthma , lung , bronchodilator , inhaler
Summary The airway response to aerosol administration of the anticholinergic agent ipratropium bromide was determined in 8 horses with recurrent airway obstruction (heaves). The reversibility of airway obstruction was confirmed by measuring lung function before and during stabling; and by determining the response to atropine administration (0.02 mg/kg bwt intravenously). The dose‐response to ipratropium bromide was determined using a Williams square design experiment in which 25, 50 or 75 μg ipratropium bromide/ml (4 ml/100 kg bwt) or the same volume of vehicle was administered to each horse by nebulisation. Lung function was measured before and 1 and 4 h after nebulisation. Vehicle had no effect on lung function. Ipratropium decreased the maximal change in pleural pressure during tidal breathing (ΔPpl max ) and pulmonary resistance (R L ) and increased dynamic compliance (C dyn ). At the 1 h measurement period, the effect on R L and C dyn was dose‐dependent. A separate experiment demonstrated that the duration of action of ipratropium was between 4 and 6 h.