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Review Article: The role of tumour necrosis factor in the pathogenesis of equine colic
Author(s) -
Morris Debra Deem
Publication year - 1992
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/j.2042-3306.1992.tb04781.x
Subject(s) - medicine , tumor necrosis factor alpha , mediator , pathogenesis , septic shock , shock (circulatory) , necrosis , monoclonal antibody , inflammation , immunology , lipopolysaccharide , sepsis , pathology , antibody
Summary A large body of evidence in experimental animals, people and now horses supports the hypothesis that tumour necrosis factor (TNF) is an important proximal mediator of endotoxaemia. Because morbidity and mortality of colic in horses are associated with the escape of lipopolysaccharide into the peripheral blood, TNF may be the trigger to the complex cascade of events that is ultimately deleterious to the host. Clinical trials of inhibiting TNF with monoclonal antibodies in human septic shock patients are being undertaken. A similar approach to treating colic in horses is warranted.