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Pharmacokinetics of tolfenamic acid in the horse
Author(s) -
JAUSSAUD P.,
GUIEU D.,
BELLON C.,
BARBIER B.,
LHOPITAL M. C.,
SECHET R.,
COURTOT D.,
TOUTAIN P. L.
Publication year - 1992
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/j.2042-3306.1992.tb04778.x
Subject(s) - horse , pharmacokinetics , pharmacology , medicine , biology , paleontology
Summary The pharmacokinetics of tolfenamic acid were studied in five ponies after an intravenous (iv) administration (2 mg/kg bodyweight [bwt]) and in four horses after an oral administration (30 mg/kg bwt) of tolfenamic acid. The plasma levels were determined by high pressure liquid chromatography (HPLC) and gas chromatography‐mass spectrometry (GC‐MS). For the iv administration, a three‐compartment model was used to represent the plasma concentration‐time curve of the drug. The elimination half‐life of the compound was 6.1 ± 1.5 h, the total body clearance was 72.4 ± 16.7 ml/kg bwt/h and the steady‐state volume of distribution 0.32 ± 0.11 litres/kg bwt. For the oral administration, absorbtion was delayed with a mean lag‐time to absorption of 32 ± 28 mins. The peak plasma concentration 11.1 ± 0.69 μg/ml was observed after a highly variable delay ranging from 1.9 to 6.5 h post administration. The terminal half‐life (4.2 ± 0.48 h) was very similar; to that obtained after iv administration. Tolfenamic acid could not be detected in equine plasma with the described analytical methods more than 48 h after drug administration.