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Inhibition of interleukin‐1 activity by equine synovial fluid
Author(s) -
MAY S. A.,
HOOKE REBECCA E.,
LEES P.
Publication year - 1992
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/j.2042-3306.1992.tb02791.x
Subject(s) - synovial fluid , interleukin , joint disease , interleukin 1β , medicine , synovial joint , lipopolysaccharide , inhibitory postsynaptic potential , chemistry , immunology , cytokine , pathology , osteoarthritis , articular cartilage , alternative medicine
Summary The presence, in equine synovial fluid, of inhibitors of interleukin‐1 (IL‐1) activity has been investigated by means of an assay involving IL‐1‐mediated production of PGE 2 by synovial cells. Inhibitors of IL‐1α and IL‐1β were identified in normal synovial fluid and synovial fluid from two horses with early joint disease. Inhibitors of IL‐1α were also present in synovial fluid from two horses with long‐standing joint disease. However, IL‐1β inhibitory activity was not present in fluid from the horses with more chronic joint disease. The effect appeared to be specific for IL‐1, and not a direct action on PGE 2 production, as synovial fluid had no effect on lipopolysaccharide‐mediated PGE 2 production. It is suggested that the inhibitory activity may be involved physiologically in the control of IL‐1 activity in the joint, and the loss of IL‐1 inhibition may be at least as important biologically as increased production of IL‐1.