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Evaluation of the haemostatic profile in the Dre‐ and post parturient mare, with particular focus on the perinatal period
Author(s) -
GENTRY P. A.,
FELDMAN B. F.,
O'NEILL S. L.,
MADIGAN J. E.,
ZINKL J. G.
Publication year - 1992
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/j.2042-3306.1992.tb02775.x
Subject(s) - fibrinogen , antithrombin , partial thromboplastin time , von willebrand factor , medicine , postpartum period , post partum , endocrinology , prothrombin time , pregnancy , chemistry , coagulation , heparin , platelet , biology , genetics
Summary Various haemostatic analytes were systematically evaluated for four months pre‐partum and five months post partum in 14 healthy mares. The plasma fibrinogen concentration and both Factor VIII:C and von Willebrand factor activity showed gradual increases from mid‐gestation and reached maximal, or near maximal activity at parturition. These increases were paralleled by an increase in plasma fibronectin concentration, the appearance of fibrinogen degradation products, and a modest rise in antithrombin III concentration. In contrast, the activity of Factor VII and Factor IX, and the one‐stage prothrombin (PT) time and the activated partial thromboplastin (APTT) time remained relatively constant throughout the pre‐ and post parturient period.