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Adverse conditions in vitro stimulate chondrocytes to produce prostaglandin E 2 and stromelysin
Author(s) -
MAY S. A.,
HOOKE REBECCA E.,
LEES P.
Publication year - 1991
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/j.2042-3306.1991.tb03742.x
Subject(s) - chondrocyte , cartilage , prostaglandin e2 , in vitro , eicosanoid , prostaglandin , chemistry , adverse effect , microbiology and biotechnology , prostaglandin e , endocrinology , medicine , pharmacology , biology , anatomy , biochemistry , enzyme , arachidonic acid
Summary Chondrocytes subjected to adverse culture conditions in vitro are stimulated to produce the eicosanoid prostaglandin E 2 (PGE 2 ) and the neutral metalloproteinase stromelysin (proteoglycanase). This indicates the potential role of the chondrocyte in cartilage degeneration in equine clinical joint disease and suggests a mechanism which may be involved in the potentiation of the effects of other inflammatory mediators. Therefore, adverse conditions within the joint, such as decreased pH in an inflammatory focus and decreased access of nutrients to deeper layers of cartilage, might contribute to the activation of chondrocytes which leads to cartilage degradation.