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The evaluation of isoxsuprine hydrochloride for the treatment of navicular disease: a double blind study
Author(s) -
TURNER A. SIMON,
TUCKER C. M.
Publication year - 1989
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/j.2042-3306.1989.tb02683.x
Subject(s) - medicine , lameness , placebo , double blind , anesthesia , surgery , pathology , alternative medicine
Summary A randomised double‐blind clinical trial of 28 horses was undertaken to evaluate the efficacy of isoxsuprine hydrochloride at four different doses:‐ 0.0 mg/kg bodyweight (bwt) (placebo), 0.6 mg/kg bwt, 1.2 mg/kg bwt and 1.8 mg/kg bwt for treatment of navicular disease. The results showed that horses treated with isoxsuprine hydrochloride (N=22) responded significantly with respect to clinical assessment score (P<0.01) when compared with the control group (N=6). Furthermore, there were no dose‐related differences in the responses of the horses treated with increasing levels of isoxsuprine. No correlation was found between radiological evidence of the extent of navicular disease and severity of lameness or response to treatment.