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Pathogenesis of degenerative joint disease
Author(s) -
CLYNE M. J.
Publication year - 1987
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/j.2042-3306.1987.tb02569.x
Subject(s) - pathogenesis , joint disease , proteoglycan , synovial fluid , pathological , disease , cartilage , microbiology and biotechnology , matrix (chemical analysis) , synovial joint , synovial membrane , extracellular matrix , enzyme , medicine , osteoarthritis , pathology , chemistry , immunology , biology , articular cartilage , inflammation , anatomy , biochemistry , alternative medicine , chromatography
Summary Proteoglycan degradation is central to the development of degenerative joint disease. Proteoglycans may be degraded by lysosomal enzymes from chondrocytes, synoviocytes or leucocytes. Collagen and matrix degradation occurs either by direct damage or due to degrading enzymes released into synovial fluid. Once the pathological sequence has begun it continues in a cyclic manner unless arrested by the ability of chondrocytes to synthesise sufficient matrix components. Treatment should ideally be directed to this end.