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Gentamicin dosage in foals aged one month and three months
Author(s) -
BAGGOT J. DESMOND,
LOVE DARIA N.,
STEWART JENNIFER,
RAUS J.
Publication year - 1986
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/j.2042-3306.1986.tb03560.x
Subject(s) - gentamicin , medicine , horse , intramuscular injection , pharmacokinetics , serum concentration , antibiotics , absorption (acoustics) , anesthesia , pharmacology , biology , microbiology and biotechnology , paleontology , physics , acoustics
Summary The absorption and disposition kinetics of gentamicin were compared at two dosage levels (2 and 4 mg/kg bodyweight [bwt]) in one‐ and three‐month‐old foals. Following intramuscular (im) injection of single 2 mg/kg bwt doses, the drug was absorbed rapidly and produced peak serum concentration (18.2 μ 5.3 ±g/ml, n = 8) at 30 mins. Much wider variations were associated with the amount of drug absorbed and the serum gentamicin concentrations after administration at the higher dosage level. The half‐life of gentamicin was similar in the one‐month‐old (3.7 ± 1.7 h, n = 8) and three‐month‐old (3.3 ± 0.8 h, n = 8) foals, and was independent of the dose. One‐month‐old foals did not appear to have a deficiency in renal excretion of gentamicin. The minimum inhibitory concentration of gentamicin for Corynebacterium equi and certain other equine bacterial isolates was less than 0.195 μg/ml. It was concluded that 2 mg/kg bwt administered by im injection at 8 to 12 h intervals, depending on the severity of the infection, could be recommended as the dose rate for treatment of systemic infections caused by microorganisms that are susceptible to gentamicin.