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Genetic control of immune responses to major histocompatibility complex antigens during equine pregnancy
Author(s) -
CRUMP ANNE L.,
DAVIES C. J.,
ANTCZAK D. F.
Publication year - 1985
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/j.2042-3306.1985.tb04599.x
Subject(s) - antigen , major histocompatibility complex , immunology , cytotoxic t cell , pregnancy , antibody , conceptus , immune system , biology , histocompatibility , human leukocyte antigen , fetus , genetics , in vitro
Summary Embryo transfer was used to establish a pregnancy in which two equine major histocompatibility complex (MHC) antigens, equine lymphocyte antigen (ELA) W2, a ‘strong’ antigen, and ELA W3, a ‘weak’ antigen, were presented together to the maternal immune system on a single conceptus. Cytotoxic antibody was first detected in the serum of the recipient mare on Day 51. Sampling was continued until Day 100, during which time antibody to ELA W2 persisted but no antibody to the W3 antigen was detected. It is clear that the maternal cytotoxic antibody response to ELA W3 in equine pregnancy is very weak relative to responses to other MHC antigens.