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Critical events surrounding the maternal recognition of pregnancy in mares
Author(s) -
SHARP D. C.,
McDOWELL KAREN J.
Publication year - 1985
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.1111/j.2042-3306.1985.tb04585.x
Subject(s) - conceptus , endometrium , prostaglandin , incubation , andrology , pregnancy , endocrinology , medicine , membrane , biology , chemistry , fetus , biochemistry , genetics
Summary An experiment was undertaken to determine whether the equine conceptus inhibits production of prostaglandin F 2α in the pregnant mare. Endometrial tissue was obtained from two normally cycling mares and conceptus membranes were obtained from a further two mares which were pregnant. Endometrial tissue was cultured alone and with conceptus membranes and the prostaglandin F 2α concentrations measured in the incubation medium over a 24 h period. With endometrium alone, prostaglandin F 2α concentrations increased slowly for the first 9 h of incubation but then began to rise sharply. When the conceptus membranes were added, the prostaglandin F 2α production rate was initially comparable to that of endometrium alone but the sharp increase seen after 9 h was large attenuated. By 18 to 24 h, the prostaglandin F 2α concentration in the endometrium plus conceptus membranes was 63 per cent less than for endometrium alone. The results corroborate previous studies that conceptus membranes can inhibit prostaglandin F 2α synthesis.