Open AccessOptimal reference interval for homeostasis model assessment of insulin resistance in a Japanese population
Author(s) -
Yamada Chizumi,
Mitsuhashi Toshitake,
Hiratsuka Noboru,
Inabe Fumiyo,
Araida Nami,
Takahashi Eiko
Publication year - 2011
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/j.2040-1124.2011.00113.x
Subject(s) - medicine , insulin resistance , diabetes mellitus , interval (graph theory) , population , homeostasis , endocrinology , environmental health , mathematics , combinatorics
The aim of the present study was to establish a reference interval for homeostasis model assessment of insulin resistance (HOMA‐IR) in a Japanese population based on the C28‐A3 document from the Clinical and Laboratory Standards Institute (CLSI). We selected healthy subjects aged 20–79 years, with fasting plasma glucose < 100 mg/dL, body mass index < 25 kg/m 2 and alanine aminotransferase < 31 U/L. HOMA‐IR values were log transformed, values beyond mean ± 3 standard deviations (SD) were truncated, and the mean ± 2 SD of log HOMA‐IR values were taken as the upper and lower reference limits of HOMA‐IR. We selected 2173 subjects as reference individuals, and 2153 subjects were used for analysis. The reference interval for HOMA‐IR was established as between 0.4 and 2.4. This represents the first reference interval study for HOMA‐IR that applies the stringent CLSI C28‐A3 document. HOMA‐IR ≥ 2.5 should be considered a reasonable indicator of insulin resistance in Japanese. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2011.00113.x, 2011)