Open AccessAge‐dependent decline in β‐cell function assessed by an oral glucose tolerance test‐based disposition index
Author(s) -
Komada Hisako,
Sakaguchi Kazuhiko,
Takeda Kazuo,
Hirota Yushi,
Hashimoto Naoko,
Okuno Yoko,
Seino Susumu,
Ogawa Wataru
Publication year - 2011
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/j.2040-1124.2010.00099.x
Subject(s) - disposition , medicine , diabetes mellitus , endocrinology , index (typography) , area under the curve , glucose tolerance test , physiology , insulin resistance , psychology , social psychology , world wide web , computer science
We evaluated age‐dependent changes in β‐cell function as assessed with an oral glucose tolerance test (OGTT)‐based analog of the disposition index (oral disposition index). A total of 110 Japanese normoglycemic subjects (aged 22–59 years) was divided into decadal age groups (20, 30, 40 and 50 s) and subjected to an OGTT. The oral disposition index was calculated as the product of the Matsuda index and the ratio of the area under the insulin curve to the area under the glucose curve for 0–120 min during the OGTT (AUC ins/gluc120 ). Although indexes of insulin secretion, including AUC ins/gluc120 and the insulinogenic index, did not differ among age groups, the oral disposition index differed significantly among decadal ages and declined with age. The oral disposition index is thus a sensitive measure of β‐cell function, and a natural decline in such function likely begins in early adulthood and progresses with age. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2010.00099.x, 2011)