Open AccessDevelopment of postpartum Graves’ disease and type 1 diabetes after delivery in a patient with gestational diabetes
Author(s) -
Negishi Mayumi,
Shimomura Kenju,
Proks Peter,
Nakahara Rieko,
Murakami Masami,
Shimomura Yohnosuke,
Kobayashi Isao
Publication year - 2011
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/j.2040-1124.2010.00089.x
Subject(s) - medicine , gestational diabetes , diabetes mellitus , pregnancy , type 1 diabetes , postpartum period , disease , etiology , autoimmune disease , type 2 diabetes , obstetrics , gestation , pediatrics , endocrinology , genetics , biology
Pregnancy and the postpartum period are associated with changes of the immune system. These changes might eventually result in autoimmune diseases, such as Graves’ disease and type 1 diabetes mellitus, in the postpartum period. We describe a case of a patient with gestational diabetes who developed both Graves’ disease and type 1 diabetes mellitus in the postpartum period. The pathology of gestational diabetes (GDM) is close to that of type 2 diabetes mellitus. However, the present case emphasizes the importance of screening and monitoring high‐risk GDM patients for all available autoimmune antibodies throughout pregnancy and the postpartum period, as GDM has a risk of developing into type 1 diabetes and multiple autoimmune diseases. In addition, only Graves’ disease was transient, whereas type 1 diabetes mellitus remained permanent in the present case. Thus, the present case shows etiological differences between these two autoimmune diseases. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2010.00089.x,2011)