Open AccessRelationship of homocysteine and homocysteine‐related vitamins to bone mineral density in Japanese patients with type 2 diabetes
Author(s) -
Yamada Chizumi,
Fujimoto Shimpei,
Ikeda Kaori,
Nomura Yuki,
Matsubara Ami,
Kanno Miwako,
Shide Kenichiro,
Tanaka Kiyoshi,
Imai Eri,
Fukuwatari Tsutomu,
Shibata Katsumi,
Inagaki Nobuya
Publication year - 2011
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/j.2040-1124.2010.00088.x
Subject(s) - medicine , homocysteine , diabetes mellitus , type 2 diabetes , bone mineral , plasma homocysteine , endocrinology , osteoporosis
Aims/Introduction: To estimate nutritional risk factors for osteoporosis in patients with type 2 diabetes, bone mineral density, homocysteine level, and intakes and levels of Hcy‐related vitamins including folate, vitamin B 6 and vitamin B 12 were analyzed in a cross‐sectional study. Materials and Methods: Lumbar spine and femoral neck bone mineral density, serum concentrations of vitamin B 6 , vitamin B 12 , and folate and plasma homocysteine levels were measured in 125 Japanese patients with type 2 diabetes. Nutrient intake values were evaluated using a food frequency questionnaire. Results: Homocysteine was inversely correlated with bone mineral density, and with both dietary intake and serum concentration of folate. Intake of green vegetables was correlated with intake and level of folate and homocysteine levels. When the population was analyzed across the quartiles, bone mineral density, serum folate concentration, folate intake and intake of green vegetables were lowest in the highest homocysteine group. Conclusions: In patients with type 2 diabetes, the nutritional status of folate might affect the homocysteine level, a putative risk factor for osteoporosis. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2010.00088.x, 2011)