Open AccessCorrelation of glycated albumin but not hemoglobin A 1c with endogenous insulin secretion in fulminant type 1 diabetes mellitus
Author(s) -
Koga Masafumi,
Murai Jun,
Saito Hiroshi,
Kasayama Soji,
Kobayashi Tetsuro,
Imagawa Akihisa,
Hanafusa Toshiaki
Publication year - 2010
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/j.2040-1124.2010.00050.x
Subject(s) - medicine , glycated hemoglobin , diabetes mellitus , endocrinology , fulminant , insulin , gastroenterology , glycated haemoglobin , urinary system , type 2 diabetes mellitus , type 2 diabetes
Aims/Introduction: Fulminant type 1 diabetes mellitus (FT1DM) develops as a result of very rapid and almost complete pancreatic β‐cell destruction. We hypothesized that in patients with FT1DM who have less endogenous insulin secretion, disease progression is more rapid, and thus glycated albumin (GA) levels are lower. This study was designed to prove this hypothesis. Materials and Methods: The present study included 42 patients with FT1DM (24 men, 18 women) in whom glycated hemoglobin (HbA 1c ), GA and daily urinary C‐peptide (CPR) were measured at the time of diagnosis. Patients with complications, such as liver disease, kidney disease, anemia, or who were pregnant were excluded. Results: Urinary CPR (log transformed) was not correlated with HbA 1c ( R = 0.168, P = 0.287), but was positively correlated with GA ( R = 0.336, P = 0.030). It was weakly, but not significantly, correlated with GA/HbA 1c ratio ( R = 0.281, P = 0.072). In patients with GA < 24.0%, urinary CPR was significantly lower than in patients with GA ≥ 24.0%. In addition, in patients with GA/HbA 1c ratio <3.8, urinary CPR was significantly lower than in patients with GA/HbA 1c ratio ≥ 3.8. Conclusions: Our findings suggest that in patients with FT1DM, GA at the time of diagnosis was correlated with endogenous insulin secretion. GA < 24.0% at the time of diagnosis is predictive for less endogenous insulin secretion in patients with FT1DM. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2010.00050.x, 2010)