Open AccessAssociation of resistin polymorphism, its serum levels and prevalence of stroke in Japanese type 2 diabetic patients
Author(s) -
Nakashima Eitaro,
Watarai Atsuko,
Tsukahara Takayoshi,
Hamada Yoji,
Naruse Keiko,
Kamiya Hideki,
Kato Jiro,
Kato Norihiro,
Tomita Makoto,
Oiso Yutaka,
Nakamura Jiro
Publication year - 2010
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/j.2040-1124.2010.00040.x
Subject(s) - resistin , medicine , odds ratio , family history , body mass index , type 2 diabetes , diabetes mellitus , endocrinology , blood pressure , insulin resistance , gastroenterology , stroke (engine) , adiponectin , insulin , mechanical engineering , engineering
Aims/Introduction: Resistin, an inflammatory cytokine, might be involved in the development of atherosclerosis. In a recent paper, we showed that resistin polymorphism might be a risk marker for stroke susceptibility in Japanese type 2 diabetic patients. We tested whether the serum resistin levels might be also a risk marker of stroke independently from RETN polymorphism. Materials and Methods: Type 2 diabetic outpatients from our hospitals were enrolled. Patients ( n = 89) with a history of coronary heart disease and stroke, and randomly selected controls ( n = 178) matched for sex and age, but without a history of coronary heart disease and stroke, were examined for polymorphism ‐420 (C>G) and cytokines levels. Results: Serum resistin levels were significantly higher in patients with cardiovascular diseases (CVD) than in those without CVD ( P = 0.024), and were highest in patients with stroke among the CVD. In multiple logistic regression analysis, serum resistin levels was an independent risk marker of stroke even after adjusted by RETN polymorphism, age, sex, body mass index, HbA 1c , systolic and diastolic blood pressure, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, creatinine, history of coronary heart disease, treatment of insulin, sulfonylurea and aspirin (odds ratio 1.33, 95% confidence interval [CI] 1.02–1.73, P = 0.039). The enrolled patients were divided by their serum resistin levels (high or low group) and their genotypes (CC, CG, GG at ‐420) into six groups. Patients with the GG genotype and high resistin levels showed the highest odds ratio, 5.69 (95% CI 1.24–26.1), compared with the group with CC and low levels. Conclusions: The results suggest that serum resistin levels might be a good marker of susceptibility to stroke as well as RETN polymorphism. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.00040.x, 2010)